Derek Sheriff has two great articles up on LewRockwell.com here and here on Nullification and the 10th Amendment.  Check them out.

Especially good is The Untold History of Nullification: Resisting Slavery.

Here's what Thomas E. Woods has to say about nullification:

If the federal government has the exclusive right to judge the extent of its own powers, warned the Kentucky and Virginia resolutions’ authors (Thomas Jefferson and James Madison, respectively), it will continue to grow – regardless of elections, the separation of powers, and other much-touted limits on government power.